Colon Cancer and Color-Blindness

https://www.bmj.com/rapid-response/2011/10/30/colour-blindness-may-be-importance-screening-colorectal-cancer

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/647272

Please read the jamanetwork article and use it to locate other articles. You can check the references and also look up the authors in pubmed to see if they have published any more recent work.

Colon Cancer and Color-Blindness

According to Weixler, Certii, & Nebiker (2015), loss of vision tends to develop over months and may be a preceding of the diagnosis of the underlying malignancy. Some patients present with visual symptoms before a cancer diagnosis while others report preceding symptoms. The relationship between colon cancer and color blindnes remains scanty. Treatment to a patient diagnosed with stage I colon cancer and with progressive loss of vision illutrate improvement of visual symptoms. The anti-retinal bodies after eight months of treatment could not be detected. However, the author fails to state if the cancer tratement helped improve visual symptoms. Again, the cancer is stage I colon cancer diagnosis not late-stage diagnosis.

Patients with advanced colon cancer on oxaliplatin treatment on a FOLFOX schedule may complain of altered color vision among others visual problems (Mesquida et al, 2010). This is an indication that the oxaliplatin treatment for colon cancer could have side effedts like altered color vision. However, there are low incidences of the association between the two making it difficult to establish any relationship.

Colon cancer can metastasize into the eye like breast and lung cancer. This could be the reason it linked to color blindness if it spreads to the eyes. Additionally, some patients may present color blindness as a symptom (Deibert et al, 2019, Ha et al, 2016). However, there is not much to support the association between the inability to see color red and colon cancer in the late stage. In conclusion, the association between inability to see color red and colon cancer in the last stage needs further research.

References Deibert., B., Ferris, L., Sanchez, N., & Weishaar, P. (2019). The link between colon cancer and congenital hypertrophy of the retinal pigment epithelium (CHRPE). American Journal of Ophthalmology Case Reports, 15:/doi.org/10.1016/j.ajoc.2019.100524. Ha., J., Jung, M., & Park, S. (2016). Choroidal and skin metastases from colorectal cancer. World Journal Gastroenterology, 22(43): 9650-9653. Mesquida, M., Pelegrin, L., Jose, J., & Adan, A. (2010). Oxaliplatin-Related Ocular Toxicity. Case Reports in Oncology, 3(3): 423–427. Weixler,B., Certii, D., & Nebiker, C. (2015). Cancer‐associated retinopathy as the leading symptom in colon cancer. Clinical Case Reports, 4(2): 171-176.

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